The M JMJD3 Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to JMJD3, and KDM6B. This antibody recognizes Human, and Mouse antigen. The M JMJD3 Antibody (Center) has been validated for the following applications: ELISA, and Western Blot.
Description
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed